Day 2 :
Keynote Forum
Hiba Kayed
The Lebanese University, Lebanon
Keynote: Oral health status and caries trend among12-year old Palestine refugee students: results from the UNRWA’s oral health surveys 2011 and 2016
Biography:
Abstract:
- Oral Pathology, Radiology, microbiology & Medicine | Oral Surgery and Dental Anaesthesiology | Periodontology and Implant Dentistry | Periodontology and Restorative Dentistry | Preventive, Community Dentistry & Oral Epidemiology | Prosthodontics & Implantology
Session Introduction
Ehsan Iranmanesh
Kerman University of Medical Sciences, Iran
Title: High performance Polymers and their application as dental implants abutment
Biography:
Ehsan Iranmanesh is serving as an assistant professor at Kerman Medical University, Iran in Iran. He has several publications on dentistry.
Abstract:
Sara Ali Swidan El-Khoriby
Suez Canal University, Egypt
Title: Synergistic therapeutic effect of nano-honokiol and 5-fluorouracil on induced-tongue cancer in rats
Biography:
Sara A. Swidan has completed her master’s degree in oral pathology from Suez Canal University in 2016. She is an assistant lecturer of oral Pathology at Faculty of dentistry, Suez Canal University, Ismailia, Egypt. Her research interest focused on the effect of phytochemicals and nano-drugs on prevention and treatment of chemically induced oral squamous cell carcinoma in animal models.
Abstract:
Objectives: To evaluate the effect of different Nano filled resin coatings on the staining susceptibility of glass ionomer restoratives after immersion in three food simulating solutions (FSS). 5-Fluorouracil (5-FU) is a common chemotherapeutic drug for treatment of oral cancer. However, its toxicity to normal tissues has limited its role as an effective cancer therapy. This research aimed to investigate the effect of combining 5-FU with honokiol (HNK) - a small natural organic molecule- on enhancing the anticancer activity of 5-FU without increasing its toxicity. Honokiol (HNK) was formulated in nano-capsules (HNK-NC) for better bioavailability, efficient penetration and sustained release. HNK-NC was used in combination with 5-FU for treatment of tongue carcinoma induced chemically by 4-nitroquinoline 1 oxide (4-NQO) in albino rats. Rats were divided into seven groups including control, 4-NQO, 5-FU, HNK, HNKNP, 5-FU with HNK, and 5-FU with HNK-NC. HNK-NC were successfully prepared using nanoprecipitation technique and transmission electron microscopy (TEM) was employed to evaluate the shape of the prepared capsules. The mean particle size was 93.93 ± 1.22 nm, with zeta potential of ±30.1 mV, and encapsulation efficiency of 99.2 ± 0.3%.. Assessment of serum levels of liver enzymes and creatinine was done to evaluate the safety of the used drugs. Serial sections of the tongues from all animals was examined microscopically and real-time PCR quantification of P53 gene expression was also assessed. The results showed that treatment with both 5-FU + HNK-NC had significantly retarded tumor growth, with a marked reduction in the systemic toxicity as compared to treatment with either drug individually. Data analysis revealed statistically significant differences (P < 0.05) in the expression levels of P53 between the combined treatment and control groups.
Nastaran Vaziri
Tehran University of Medical Sciences, Iran
Title: Conventional method versus automatic injection for infiltration anesthesia in the premolar region
Biography:
Abstract:
Pain control by local anesthesia plays a critical role in success of most dental treatments. Due to the unpleasant pain experience related to the use of the conventional syringe injection, some computerized techniques have been developed for local anesthetic injection. This study aimed to compare the pain score following infiltration anesthesia of the maxillary premolar teeth administered by the conventional syringe and automatic. This single-bind randomized clinical trial was performed on 35 patients whose average age was 38. Requiring bilateral extraction of maxillary premolars. The patients’ dental anxiety was scored and they received infiltration anesthesia with the iCT injection SE (Dentium, South Korea) at one side and conventional syringe at the contralateral side. The pain level was recorded during needle insertion, anesthetic delivery and 5 hours after the injection using visual analog scale (VAS) and the face rating scale (FRS). The data were subjected to Wilcoxon signed-rank test. Significant differences were found between the automatic and conventional methods regarding pain scores during needle insertion (P<0.01) and anesthetic delivery (P<0.0001) while no significant differences were noted at 5 hours after the injection. Pain scores were significantly lower during supra-periosteal injections in the maxillary premolar region using iCT injection. Both FRS and VAS in iCT injection showed that frequency of severe pain during needle insertion and anesthetic delivery was noticeably lower than that in conventional injection method but findings revealed that there was no significant difference between these two technics after 5 hours of injection.
Biography:
Wiem Bouaziz-Zouaoui works at Periosystem in France. Her research interests are Periodontology, Oral & Maxillofacial surgery.